STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Developing B cells show enhanced sensitivity to negatively selecting signals. Weiss and colleagues show that calcium signals arising from activation of the calcium sensor STIM1 lead to activation of Erk and apoptosis via a protein kinase C-δ and the guanine nucleotide-exchange factor RasGRP1-dependent pathway in transitional self-reactive B cells.<...
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STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
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TN_cdi_hal_primary_oai_HAL_hal_04602984v1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04602984v1
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2016
