SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK i...
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
About this item
Full title
Author / Creator
Dardaei, Leila , Wang, Hui Qin , Singh, Manrose , Fordjour, Paul , Shaw, Katherine X , Yoda, Satoshi , Kerr, Grainne , Yu, Kristine , Liang, Jinsheng , Cao, Yichen , Chen, Yan , Lawrence, Michael S , Langenbucher, Adam , Gainor, Justin F , Friboulet, Luc , Dagogo-Jack, Ibiayi , Myers, David T , Labrot, Emma , Ruddy, David , Parks, Melissa , Lee, Dana , DiCecca, Richard H , Moody, Susan , Hao, Huaixiang , Mohseni, Morvarid , LaMarche, Matthew , Williams, Juliet , Hoffmaster, Keith , Caponigro, Giordano , Shaw, Alice T , Hata, Aaron N , Benes, Cyril H , Li, Fang and Engelman, Jeffrey A
Publisher
New York: Springer New York
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
Genomic and drug screens identify SHP2 blockade as a therapeutic approach for ALK-rearranged non-small cell lung cancers developing resistance through ALK-mutant-independent mechanisms.
Most anaplastic lymphoma kinase (
ALK
)-rearranged non-small-cell lung tumors initially respond to small-molecule ALK inhibitors, but drug resistance often...
Alternative Titles
Full title
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
Authors, Artists and Contributors
Author / Creator
Wang, Hui Qin
Singh, Manrose
Fordjour, Paul
Shaw, Katherine X
Yoda, Satoshi
Kerr, Grainne
Yu, Kristine
Liang, Jinsheng
Cao, Yichen
Chen, Yan
Lawrence, Michael S
Langenbucher, Adam
Gainor, Justin F
Friboulet, Luc
Dagogo-Jack, Ibiayi
Myers, David T
Labrot, Emma
Ruddy, David
Parks, Melissa
Lee, Dana
DiCecca, Richard H
Moody, Susan
Hao, Huaixiang
Mohseni, Morvarid
LaMarche, Matthew
Williams, Juliet
Hoffmaster, Keith
Caponigro, Giordano
Shaw, Alice T
Hata, Aaron N
Benes, Cyril H
Li, Fang
Engelman, Jeffrey A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04633807v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04633807v1
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X,1744-7933
DOI
10.1038/nm.4497
