Pancreas-directed AAV8-hSPINK1 gene therapy safely and effectively protects against pancreatitis in...
Pancreas-directed AAV8-hSPINK1 gene therapy safely and effectively protects against pancreatitis in mice
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Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
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Scope and Contents
Contents
ObjectiveCurrently, there is no cure for chronic pancreatitis (CP). Germline loss-of-function variants in SPINK1 (encoding trypsin inhibitor) are common in patients with CP and are associated with acute attacks and progression of the disease. This preclinical study was conducted to explore the potential of adeno-associated virus type 8 (AAV8)-media...
Alternative Titles
Full title
Pancreas-directed AAV8-hSPINK1 gene therapy safely and effectively protects against pancreatitis in mice
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Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04668698v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04668698v1
Other Identifiers
ISSN
0017-5749,1468-3288
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2023-330788
