Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
BRET probes that monitor activation of multiple G protein isoforms reveal that angiotensin II and a biased agonist of the angiotensin II type 1A receptor stabilize distinct receptor conformations associated with different signaling outputs.
Functional selectivity of G protein–coupled receptor (GPCR) ligands toward different downstream signals ha...
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Full title
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
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TN_cdi_hal_primary_oai_HAL_inserm_00755334v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_00755334v1
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.961
