Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic consideratio...
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
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Publisher
England: Elsevier Ltd
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Language
English
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Publisher
England: Elsevier Ltd
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Contents
Summary Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and widespread aggregation of the α-synuclein protein in the form of Lewy bodies and Lewy neurites are neuropathological hallmarks of Parkinson's disease. Most cases occur sporadically, but mutations in several genes, including SNCA , which encodes α-synu...
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Full title
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
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TN_cdi_hal_primary_oai_HAL_inserm_02439371v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_02439371v1
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ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(15)00006-X
