Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophi...
Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina
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Author / Creator
Ameline, B , Tshilenge, K-T , Weber, M , Biget, M , Libeau, L , Caplette, R , Mendes-Madeira, A , Provost, N , Guihal, C , Picaud, S , Moullier, P , Pichard, V , Cronin, T and Isiegas, C
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Several preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-def...
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Full title
Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina
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Record Identifier
TN_cdi_hal_primary_oai_HAL_inserm_02894245v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_02894245v1
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ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/gt.2017.63