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Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophi...

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_02894245v1

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina

About this item

Full title

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina

Publisher

London: Nature Publishing Group UK

Journal title

Gene therapy, 2017-11, Vol.24 (11), p.735-741

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Several preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-def...

Alternative Titles

Full title

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_hal_primary_oai_HAL_inserm_02894245v1

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_02894245v1

Other Identifiers

ISSN

0969-7128

E-ISSN

1476-5462

DOI

10.1038/gt.2017.63

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