Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits...
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
About this item
Full title
Author / Creator
Richetin, Kevin , Steullet, Pascal , Pachoud, Mathieu , Perbet, Romain , Parietti, Enea , Maheswaran, Mathischan , Eddarkaoui, Sabiha , Bégard, Séverine , Pythoud, Catherine , Rey, Maria , Caillierez, Raphaëlle , Q Do, Kim , Halliez, Sophie , Bezzi, Paola , Buée, Luc , Leuba, Geneviève , Colin, Morvane , Toni, Nicolas and Déglon, Nicole
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Alzheimer’s disease (AD) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain of events remains unclear. In the present study, we found accumulation of tau in hilar astrocytes of the dentate gyrus of individuals with AD. In mice, the overexpressi...
Alternative Titles
Full title
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Authors, Artists and Contributors
Author / Creator
Steullet, Pascal
Pachoud, Mathieu
Perbet, Romain
Parietti, Enea
Maheswaran, Mathischan
Eddarkaoui, Sabiha
Bégard, Séverine
Pythoud, Catherine
Rey, Maria
Caillierez, Raphaëlle
Q Do, Kim
Halliez, Sophie
Bezzi, Paola
Buée, Luc
Leuba, Geneviève
Colin, Morvane
Toni, Nicolas
Déglon, Nicole
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_inserm_03366740v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_03366740v1
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-020-00728-x
