Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregu...
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
About this item
Full title
Author / Creator
Khelfaoui, Malik , Gambino, Frédéric , Houbaert, Xander , Ragazzon, Bruno , Müller, Christian , Carta, Mario , Lanore, Frédéric , Srikumar, Bettadapura N. , Gastrein, Philippe , Lepleux, Marilyn , Zhang, Chun-Lei , Kneib, Marie , Poulain, Bernard , Reibel-Foisset, Sophie , Vitale, Nicolas , Chelly, Jamel , Billuart, Pierre , Lüthi, Andreas and Humeau, Yann
Publisher
England: The Royal Society
Journal title
Language
English
Formats
Publication information
Publisher
England: The Royal Society
Subjects
More information
Scope and Contents
Contents
Loss-of-function mutations in the gene encoding for the RhoGAP protein of oligophrenin-1 (OPHN1) lead to cognitive disabilities (CDs) in humans, yet the underlying mechanisms are not known. Here, we show that in mice constitutive lack of Ophn1 is associated with dysregulation of the cyclic adenosine monophosphate/phosphate kinase A (cAMP/PKA) signa...
Alternative Titles
Full title
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
Authors, Artists and Contributors
Author / Creator
Gambino, Frédéric
Houbaert, Xander
Ragazzon, Bruno
Müller, Christian
Carta, Mario
Lanore, Frédéric
Srikumar, Bettadapura N.
Gastrein, Philippe
Lepleux, Marilyn
Zhang, Chun-Lei
Kneib, Marie
Poulain, Bernard
Reibel-Foisset, Sophie
Vitale, Nicolas
Chelly, Jamel
Billuart, Pierre
Lüthi, Andreas
Humeau, Yann
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_istex_primary_ark_67375_V84_MH5SW5SK_3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_istex_primary_ark_67375_V84_MH5SW5SK_3
Other Identifiers
ISSN
0962-8436
E-ISSN
1471-2970
DOI
10.1098/rstb.2013.0160
