A Molecular Basis for Nitric Oxide Sensing by Soluble Guanylate Cyclase
A Molecular Basis for Nitric Oxide Sensing by Soluble Guanylate Cyclase
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Nitric oxide (NO) functions as a signaling agent by activation of the soluble isoform of guanylate cyclase (sGC), a heterodimeric hemoprotein. NO binds to the heme of sGC and triggers formation of cGMP from GTP. Here we report direct kinetic measurements of the multistep binding of NO to sGC and correlate these presteady state events with activatio...
Alternative Titles
Full title
A Molecular Basis for Nitric Oxide Sensing by Soluble Guanylate Cyclase
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Author / Creator
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Record Identifier
TN_cdi_jstor_primary_121154
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_121154
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.26.14753
