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Regeneration of β -adrenergic Receptors in Senescent Rats: A Study Using an Irreversible Binding Ant...

Regeneration of β -adrenergic Receptors in Senescent Rats: A Study Using an Irreversible Binding Ant...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_12606

Regeneration of β -adrenergic Receptors in Senescent Rats: A Study Using an Irreversible Binding Antagonist

About this item

Full title

Regeneration of β -adrenergic Receptors in Senescent Rats: A Study Using an Irreversible Binding Antagonist

Publisher

United States: National Academy of Sciences of the United States of America

Journal title

Proceedings of the National Academy of Sciences - PNAS, 1982-07, Vol.79 (14), p.4424-4427

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences of the United States of America

More information

Scope and Contents

Contents

The drug used in this study, bromoacetylalprenololmenthane, has the ability to bind and block irreversibly β -adrenergic receptors. The drug was bound to membranes prepared from hearts, lungs, and brains of both senescent and young rats with a similar affinity. When this drug was injected into rats in nontoxic doses (up to 70 mg/kg), up to 90% of β...

Alternative Titles

Full title

Regeneration of β -adrenergic Receptors in Senescent Rats: A Study Using an Irreversible Binding Antagonist

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_12606

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_12606

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.79.14.4424

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