A Single Negative Charge within the Pore Region of a cGMP-Gated Channel Controls Rectification, Ca2+...
A Single Negative Charge within the Pore Region of a cGMP-Gated Channel Controls Rectification, Ca2+Blockage, and Ionic Selectivity
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Contents
Ca2+ions control the cGMP-gated channel of rod photoreceptor cells from the external and internal face. We studied ion selectivity and blockage by Ca2+of wild-type and mutant channels in a heterologous expression system. External Ca2+blocks the inward current at micromolar concentrations in a highly voltage-dependent manner. The blockage at negativ...
Alternative Titles
Full title
A Single Negative Charge within the Pore Region of a cGMP-Gated Channel Controls Rectification, Ca2+Blockage, and Ionic Selectivity
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Record Identifier
TN_cdi_jstor_primary_2363874
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_2363874
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.91.3.1109
