PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
There has been increasing interest in the use of isoform-selective inhibitors of phosphatidylinositide-3-kinase (PI3K) in cancer therapy. Using conditional deletion of the p110 catalytic isoforms of PI3K to predict sensitivity of cancer types to such inhibitors, we and others have demonstrated that tumors deficient of the phosphatase and tensin hom...
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Full title
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
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TN_cdi_jstor_primary_23772510
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_23772510
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1323004111
