Par4 Is Required for Platelet Thrombus Propagation but Not Fibrin Generation in a Mouse Model of Thr...
Par4 Is Required for Platelet Thrombus Propagation but Not Fibrin Generation in a Mouse Model of Thrombosis
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Thrombin, a central mediator of hemostasis and thrombosis, converts fibrinogen to fibrin and is a potent platelet activator. Activated platelets provide a surface for assembly of the tenase and prothrombinase complexes required for thrombin generation. The role of thrombin-induced platelet activation in platelet accumulation and its interplay with...
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Full title
Par4 Is Required for Platelet Thrombus Propagation but Not Fibrin Generation in a Mouse Model of Thrombosis
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TN_cdi_jstor_primary_25426090
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25426090
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0610188104
