Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
During kidney organogenesis, tubular epithelial cells proliferate until a functional tubule is formed as sensed by cilia bending in response to fluid flow. This flow-induced ciliary mechanosensation opens the calcium (Ca²⁺) channel polycystin-2 (PC2), resulting in a calcium flux-mediated cell cycle arrest. Loss or mutation of either PC2 or its regu...
Alternative Titles
Full title
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
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Record Identifier
TN_cdi_jstor_primary_25426843
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25426843
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0700499104
