Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitoc...
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Cu, Zn superoxide dismutase (SOD1) has been detected within spinal cord mitochondria of mutant SOD1 transgenic mice, a model of familial ALS. The copper chaperone for SOD1 (CCS) provides SOD1 with copper, facilitates the conversion of immature apo-SOD1 to a mature holoform, and influences in yeast the cytosolic/mitochondrial partitioning of SOD1. T...
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Full title
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology
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TN_cdi_jstor_primary_25427328
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25427328
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0610923104
