βKlotho Is Required for Metabolic Activity of Fibroblast Growth Factor 21
βKlotho Is Required for Metabolic Activity of Fibroblast Growth Factor 21
About this item
Full title
Author / Creator
Publisher
National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes. Here, we show that FGF21 activity depends on βKlotho, a single-pass transmembrane protein whose expression is induced during differentiation from preadipocytes to adipocytes. βKlotho physically interacts with FGF receptors 1c and 4,...
Alternative Titles
Full title
βKlotho Is Required for Metabolic Activity of Fibroblast Growth Factor 21
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_jstor_primary_25427504
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25427504
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0701600104
