Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
cAMP is well known to regulate exocytosis in various secretory cells, but the precise mechanism of its action remains unknown. Here, we examine the role of cAMP signaling in the exocytotic process of insulin granules in pancreatic beta cells. Although activation of cAMP signaling alone does not cause fusion of the granules to the plasma membrane, i...
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Full title
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
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TN_cdi_jstor_primary_25450710
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25450710
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0707054104
