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Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormon...

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormon...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25450714

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

About this item

Full title

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (49), p.19357-19362

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Blastocyst implantation is a critical stage in the establishment of pregnancy. Leukemia inhibitory factor (LIF) is essential for mouse blastocyst implantation and also plays a role in human pregnancy. We examined the effect of a potent LIF antagonist (LA) on mouse implantation. In mice, LIF expression peaks on day 3.5 of pregnancy (D3.5) (D0.5 = da...

Alternative Titles

Full title

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_25450714

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25450714

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0710110104

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