Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheime...
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
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Author / Creator
Coomaraswamy, Janaky , Kilger, Ellen , Wölfing, Heidrun , Schäfer, Claudia , Kaeser, Stephan A , Wegenast-Braun, Bettina M , Hefendehl, Jasmin K , Wolburg, Hartwig , Mazzella, Matthew , Ghiso, Jorge , Goedert, Michel , Akiyama, Haruhiko , Garcia-Sierra, Francisco , Wolfer, David P , Mathews, Paul M and Jucker, Mathias
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse models of familial Danish dementia that exhibit the age-de...
Alternative Titles
Full title
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
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Record Identifier
TN_cdi_jstor_primary_25665468
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25665468
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1001056107
