Pathology tissue—chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the...
Pathology tissue—chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Epigenetic alterations in the pattern of DNA and histone modifications play a crucial role in cancer development. Analysis of patient samples, however, is hampered by technical limitations in the study of chromatin structure from pathology archives that usually consist of heavily fixed, paraffin-embedded material. Here, we present a methodology [pa...
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Pathology tissue—chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
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TN_cdi_jstor_primary_25756919
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25756919
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1007647107