α-Synuclein, a chemoattractant, directs microglial migration via H₂O₂-dependent Lyn phosphorylation
α-Synuclein, a chemoattractant, directs microglial migration via H₂O₂-dependent Lyn phosphorylation
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Malformed α-Synuclein (α-syn) aggregates in neurons are released into the extracellular space, activating microglia to induce chronic neuroinflammation that further enhances neuronal damage in α-synucleinopathies, such as Parkinson’s disease. The mechanisms by which α-syn aggregates activate and recruit microglia remain unclear, however. Here we sh...
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Full title
α-Synuclein, a chemoattractant, directs microglial migration via H₂O₂-dependent Lyn phosphorylation
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TN_cdi_jstor_primary_26462261
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26462261
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1417883112
