Origins of stereoselectivity in evolved ketoreductases
Origins of stereoselectivity in evolved ketoreductases
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Author / Creator
Noey, Elizabeth L. , Tibrewal, Nidhi , Jiménez-Osés, Gonzalo , Osuna, Sílvia , Park, Jiyong , Bond, Carly M. , Cascio, Duilio , Liang, Jack , Zhang, Xiyun , Huisman, Gjalt W. , Tang, Yi , Houk, Kendall N. , Argonne National Laboratory (ANL), Argonne, IL (United States) and Univ. of California, Los Angeles, CA (United States)
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Mutants ofLactobacillus kefirshort-chain alcohol dehydrogenase, used here as ketoreductases (KREDs), enantioselectively reduce the pharmaceutically relevant substrates 3-thiacyclopentanone and 3-oxacyclopentanone. These substrates differ by only the heteroatom (S or O) in the ring, but the KRED mutants reduce them with different enantioselectivitie...
Alternative Titles
Full title
Origins of stereoselectivity in evolved ketoreductases
Authors, Artists and Contributors
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Record Identifier
TN_cdi_jstor_primary_26466210
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26466210
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1507910112
