Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protract...
Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
A major hypothesis in addiction research is that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadaptations represent a key neurochemical event in compulsive drug use and relapse. Whether these neuroadaptations lead to a hypo- or hyperdopaminergic state during abstinence is a long-standing, unresolved de...
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Full title
Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence
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TN_cdi_jstor_primary_26468687
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26468687
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1506012113
