Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
cAMP signaling plays a key role in regulating pain sensitivity. Here, we uncover a previously unidentified molecular mechanism in which direct phosphorylation of the exchange protein directly activated by cAMP 1 (EPAC1) by G protein kinase 2 (GRK2) suppresses Epac1-to-Rap1 signaling, thereby inhibiting persistent inflammatory pain. Epac1−/− mice ar...
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Full title
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1
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TN_cdi_jstor_primary_26468689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26468689
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1516036113
