The Role of Platelet Adhesion Receptor GPIbα Far Exceeds That of Its Main Ligand, von Willebrand Fac...
The Role of Platelet Adhesion Receptor GPIbα Far Exceeds That of Its Main Ligand, von Willebrand Factor, in Arterial Thrombosis
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Publisher
National Academy of Sciences
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Language
English
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National Academy of Sciences
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GPIbα binding to von Willebrand factor (VWF) exposed at a site of vascular injury is thought to be the first step in the formation of a hemostatic plug. However, our previous studies in VWF-deficient mice demonstrated delayed but not absent arterial thrombus formation, suggesting that, under these conditions, GPIbα may bind other ligands or that a...
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Full title
The Role of Platelet Adhesion Receptor GPIbα Far Exceeds That of Its Main Ligand, von Willebrand Factor, in Arterial Thrombosis
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TN_cdi_jstor_primary_30051767
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_30051767
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0608207103
