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Evidence for a Cytopathogenicity Determinant in HIV-1 Vpr

Evidence for a Cytopathogenicity Determinant in HIV-1 Vpr

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_3059228

Evidence for a Cytopathogenicity Determinant in HIV-1 Vpr

About this item

Full title

Evidence for a Cytopathogenicity Determinant in HIV-1 Vpr

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9503-9508

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

HIV-1 is cytopathic for CD4+ T lymphocytes in vitro and this property of HIV-1 is generally considered to account for some of its in vivo cytopathogenicity. Thus, the extent of lymphocyte depletion correlates with the level of viremia whereas low levels of viral replication are typically associated with stable lymphocyte levels and asymptomatic inf...

Alternative Titles

Full title

Evidence for a Cytopathogenicity Determinant in HIV-1 Vpr

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_3059228

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_3059228

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.142313699

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