Molecular Bases of Defective Signal Transduction in the Platelet P2Y12Receptor of a Patient with Con...
Molecular Bases of Defective Signal Transduction in the Platelet P2Y12Receptor of a Patient with Congenital Bleeding
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National Academy of Sciences
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English
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National Academy of Sciences
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We have identified structural attributes required for signal transduction through a seven-transmembrane-domain receptor. Platelets from a patient (AC) with a congenital bleeding disorder had normal shape change but reduced and reversible aggregation in response to$4\>\mu M$ADP, similar to normal platelets with blocked P2Y12receptor. The response to...
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Molecular Bases of Defective Signal Transduction in the Platelet P2Y12Receptor of a Patient with Congenital Bleeding
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TN_cdi_jstor_primary_3138470
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_3138470
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0027-8424
