Prion-like propagation of mutant Superoxide dismutase-1 misfolding in neuronal cells
Prion-like propagation of mutant Superoxide dismutase-1 misfolding in neuronal cells
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Deposition of proteins of aberrant conformation is the hallmark of many neurodegenerative diseases. Misfolding of the normally globular mutant Superoxide dismutase-1 (SOD1) is a central, early, but poorly understood event in the pathogenic cascade leading to familial forms of ALS. Here we report that aggregates composed of an ALS-causing SOD1 mutan...
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Full title
Prion-like propagation of mutant Superoxide dismutase-1 misfolding in neuronal cells
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TN_cdi_jstor_primary_41060969
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_41060969
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1017275108
