Inactivation of the Snf5 Tumor Suppressor Stimulates Cell Cycle Progression and Cooperates with p53...
Inactivation of the Snf5 Tumor Suppressor Stimulates Cell Cycle Progression and Cooperates with p53 Loss in Oncogenic Transformation
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Snf5 (Ini1/Baf47/Smarcb1), a core member of the Swi/Snf chromatin remodeling complex, is a potent tumor suppressor whose mechanism of action is largely unknown. Biallelic loss of Snf5 leads to the onset of aggressive cancers in both humans and mice. We have developed an innovative and widely applicable analytical technique for cross-species validat...
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Full title
Inactivation of the Snf5 Tumor Suppressor Stimulates Cell Cycle Progression and Cooperates with p53 Loss in Oncogenic Transformation
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TN_cdi_jstor_primary_4152798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_4152798
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0509014102
