Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Procaspase-3 (P3) and procaspase-7 (P7) are activated through proteolytic maturation to form caspase-3 (C3) and caspase-7 (C7), respectively, which serve overlapping but nonredundant roles as the executioners of apoptosis in humans. However, it is unclear if differences in P3 and P7 maturation mechanisms underlie their unique biological functions,...
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Full title
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
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TN_cdi_jstor_primary_42656748
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_42656748
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1306759110
