Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer’s disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, we use a combination of kinetic...
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Full title
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
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TN_cdi_jstor_primary_42706078
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_42706078
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1218402110
