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Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_63939

Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

About this item

Full title

Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

Publisher

United States: National Academy of Sciences of the United States of America

Journal title

Proceedings of the National Academy of Sciences - PNAS, 1974-12, Vol.71 (12), p.4910-4914

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences of the United States of America

More information

Scope and Contents

Contents

Kirromycin, a new inhibitor of protein synthesis, is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu (EF-Tu). All the reactions associated with this elongation factor are affected. Formation of the EF-Tu· GTP complex is strongly stimulated. Peptide bond formation is prevented only when Phe-tRNAPheis bound enz...

Alternative Titles

Full title

Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_63939

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_63939

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.71.12.4910

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