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Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hyp...

Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hyp...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_nrcresearch_primary_10_1139_cjpp_2019_0656

Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension1

About this item

Full title

Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension1

Publisher

1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7: NRC Research Press

Journal title

Canadian journal of physiology and pharmacology, 2020, Vol.98 (9), p.625-628

Language

English

Formats

Publication information

Publisher

1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7: NRC Research Press

More information

Scope and Contents

Contents

Bosentan, an endothelin receptor antagonist, has been widely used as a first-line medication for the treatment of pulmonary arterial hypertension (PAH). It has been shown to improve symptoms of hypertension, exercise capacity, and hemodynamics and prolong time to clinical worsening. However, liver dysfunction is a major side effect of bosentan trea...

Alternative Titles

Full title

Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_nrcresearch_primary_10_1139_cjpp_2019_0656

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_nrcresearch_primary_10_1139_cjpp_2019_0656

Other Identifiers

ISSN

0008-4212

E-ISSN

1205-7541

DOI

10.1139/cjpp-2019-0656

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