Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by stabilizing lysosomal membrane perm...
Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by stabilizing lysosomal membrane permeabilization and increasing collagen degradation
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Excessive oxidative stress causes lysosomal membrane permeabilization (LMP), which leads to cell death. Vacuolar ATPase (V-ATPase) is the enzyme responsible for pumping H
+
into the cytosol and thus maintaining intracellular pH. Previously, we reported that V-ATPase B2 subunit expression is upregulated in the TiO
2
-exposed lung epithel...
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Full title
Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by stabilizing lysosomal membrane permeabilization and increasing collagen degradation
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TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10030809
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10030809
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ISSN
2092-6413,1226-3613
E-ISSN
2092-6413
DOI
10.1038/s12276-022-00776-2
