Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electrophoretic mobility gel shift assay (EMSA) and filter binding assay. Of 179 chemicals screened, we identified three with a half-maximal inhibitory...
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Full title
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
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TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_1089509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_1089509
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ISSN
1226-3613
E-ISSN
2092-6413
DOI
10.3858/emm.2009.41.11.088
