Illuminating the mechanistic roles of enzyme conformational dynamics
Illuminating the mechanistic roles of enzyme conformational dynamics
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Many enzymes mold their structures to enclose substrates in their active sites such that conformational remodeling may be required during each catalytic cycle. In adenylate kinase (AK), this involves a large-amplitude rearrangement of the enzyme's lid domain. Using our method of high-resolution single-molecule FRET, we directly followed AK's domain...
Alternative Titles
Full title
Illuminating the mechanistic roles of enzyme conformational dynamics
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Record Identifier
TN_cdi_osti_scitechconnect_1001563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1001563
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0708600104
