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Structure and mechanism of the UvrA–UvrB DNA damage sensor

Structure and mechanism of the UvrA–UvrB DNA damage sensor

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1037482

Structure and mechanism of the UvrA–UvrB DNA damage sensor

About this item

Full title

Structure and mechanism of the UvrA–UvrB DNA damage sensor

Publisher

New York: Nature Publishing Group US

Journal title

Nature structural & molecular biology, 2012-03, Vol.19 (3), p.291-298

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

The bacterial nucleotide excision repair pathway starts with the sensor complex UvrA–UvrB scanning the genome and undergoing conformational change when DNA lesions are detected. Now crystal structures of a UvrA dimer and the UvrA–UvrB complex, along with biochemical analyses, provide insight into these early nucleotide excision repair events.
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Alternative Titles

Full title

Structure and mechanism of the UvrA–UvrB DNA damage sensor

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_osti_scitechconnect_1037482

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1037482

Other Identifiers

ISSN

1545-9993

E-ISSN

1545-9985

DOI

10.1038/nsmb.2240

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