Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1
Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Poly(ADP-ribose) polymerase-1 (PARP-1) (ADP, adenosine diphosphate) has a modular domain architecture that couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly understood mechanism. Here, we report the crystal structure of a DNA double-strand break in complex with human PARP-1 domains essential for activation (Zn1, Zn3,...
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Full title
Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1
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TN_cdi_osti_scitechconnect_1069586
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1069586
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1216338
