Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 com...
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Helper T-cell activation generally requires the coreceptor CD4, which binds MHC class II molecules. A remarkable feature of the CD4-MHC class II interaction is its exceptionally low affinity, which ranges from KD = ~ 200 μM to > 2 mM. Investigating the biological role of the much lower affinity of this interaction than those of other cell-cell reco...
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Full title
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex
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TN_cdi_osti_scitechconnect_1069727
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1069727
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1109438108
