Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Members of the SAM-dependent methyltransferase superfamily are involved in the modification of wobble uridine to 5-oxacetyl uridine in Gram-negative bacteria; CmoA converts SAM to carboxy-SAM (Cx-SAM; a metabolite that was unknown previously), and CmoB uses Cx-SAM to convert 5-hydroxyuridine to 5-oxyacetyl uridine in tRNA.
Hidden metabolite has...
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Full title
Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
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TN_cdi_osti_scitechconnect_1109747
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1109747
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12180
