A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
About this item
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Author / Creator
Chan-Penebre, Elayne , Kuplast, Kristy G , Majer, Christina R , Boriack-Sjodin, P Ann , Wigle, Tim J , Johnston, L Danielle , Rioux, Nathalie , Munchhof, Michael J , Jin, Lei , Jacques, Suzanne L , West, Kip A , Lingaraj, Trupti , Stickland, Kimberly , Ribich, Scott A , Raimondi, Alejandra , Scott, Margaret Porter , Waters, Nigel J , Pollock, Roy M , Smith, Jesse J , Barbash, Olena , Pappalardi, Melissa , Ho, Thau F , Nurse, Kelvin , Oza, Khyati P , Gallagher, Kathleen T , Kruger, Ryan , Moyer, Mikel P , Copeland, Robert A , Chesworth, Richard , Duncan, Kenneth W and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Protein methyltransferase PRMT5 symmetrically dimethylates arginine residues in proteins, including histones, and has been associated with tumorigenesis. The identification of EPZ015666 as a potent chemical probe of PRMT5 could promote understanding of the role of PRMT5 in human disease both in cells and
in vivo
.
Protein arginine methyltr...
Alternative Titles
Full title
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Authors, Artists and Contributors
Author / Creator
Kuplast, Kristy G
Majer, Christina R
Boriack-Sjodin, P Ann
Wigle, Tim J
Johnston, L Danielle
Rioux, Nathalie
Munchhof, Michael J
Jin, Lei
Jacques, Suzanne L
West, Kip A
Lingaraj, Trupti
Stickland, Kimberly
Ribich, Scott A
Raimondi, Alejandra
Scott, Margaret Porter
Waters, Nigel J
Pollock, Roy M
Smith, Jesse J
Barbash, Olena
Pappalardi, Melissa
Ho, Thau F
Nurse, Kelvin
Oza, Khyati P
Gallagher, Kathleen T
Kruger, Ryan
Moyer, Mikel P
Copeland, Robert A
Chesworth, Richard
Duncan, Kenneth W
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1244721
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1244721
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1810
