Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
About this item
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Author / Creator
Ahuja, Shivani , Mukund, Susmith , Deng, Lunbin , Khakh, Kuldip , Chang, Elaine , Ho, Hoangdung , Shriver, Stephanie , Young, Clint , Lin, Sophia , Johnson, J. P. , Wu, Ping , Li, Jun , Coons, Mary , Tam, Christine , Brillantes, Bobby , Sampang, Honorio , Mortara, Kyle , Bowman, Krista K. , Clark, Kevin R. , Estevez, Alberto , Xie, Zhiwei , Verschoof, Henry , Grimwood, Michael , Dehnhardt, Christoph , Andrez, Jean–Christophe , Focken, Thilo , Sutherlin, Daniel P. , Safina, Brian S. , Starovasnik, Melissa A. , Ortwine, Daniel F. , Franke, Yvonne , Cohen, Charles J. , Hackos, David H. , Koth, Christopher M. and Payandeh, Jian
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Voltage-gated sodium (Nav) channels propagate action potentials in excitable cells. Accordingly, Nav channels are therapeutic targets for many cardiovascular and neurological disorders. Selective inhibitors have been challenging to design because the nine mammalian Nav channel isoforms share high sequence identity and remain recalcitrant to high-re...
Alternative Titles
Full title
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
Authors, Artists and Contributors
Author / Creator
Mukund, Susmith
Deng, Lunbin
Khakh, Kuldip
Chang, Elaine
Ho, Hoangdung
Shriver, Stephanie
Young, Clint
Lin, Sophia
Johnson, J. P.
Wu, Ping
Li, Jun
Coons, Mary
Tam, Christine
Brillantes, Bobby
Sampang, Honorio
Mortara, Kyle
Bowman, Krista K.
Clark, Kevin R.
Estevez, Alberto
Xie, Zhiwei
Verschoof, Henry
Grimwood, Michael
Dehnhardt, Christoph
Andrez, Jean–Christophe
Focken, Thilo
Sutherlin, Daniel P.
Safina, Brian S.
Starovasnik, Melissa A.
Ortwine, Daniel F.
Franke, Yvonne
Cohen, Charles J.
Hackos, David H.
Koth, Christopher M.
Payandeh, Jian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1355830
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1355830
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aac5464
