Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Nonribosomal depsipeptides are natural products composed of amino and hydroxy acid residues. The hydroxy acid residues often derive from α-keto acids, reduced by ketoreductase domains in the depsipeptide synthetases. Biochemistry and structures reveal the mechanism of discrimination for α-keto acids and a remarkable architecture: flanking intact ad...
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Full title
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis
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TN_cdi_osti_scitechconnect_1616615
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1616615
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0481-5
