Crystal structure of E. coli PRPP synthetase

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1618613

Crystal structure of E. coli PRPP synthetase

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Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Zhou, Weijie , Tsai, Andrew , Dattmore, Devon A. , Stives, Devin P. , Chitrakar, Iva , D’alessandro, Alexis M. , Patil, Shiv , Hicks, Katherine A. and French, Jarrod B.

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United Kingdom: Springer Science + Business Media

Journal title

BMC structural biology, 2019-01, Vol.19 (1)

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English

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United Kingdom: Springer Science + Business Media

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Contents

Ribose-phosphate pyrophosphokinase (EC 2.7.6.1) is an enzyme that catalyzes the ATP-dependent conversion of ribose-5-phosphate to phosphoribosyl pyrophosphate. The reaction product is a key precursor for the biosynthesis of purine and pyrimidine nucleotides. We report the 2.2 Å crystal structure of the E. coli ribose-phosphate pyrophosphobinase (Ec...