Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
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Author / Creator
Gallagher-Jones, Marcus , Glynn, Calina , Boyer, David R. , Martynowycz, Michael W. , Hernandez, Evelyn , Miao, Jennifer , Zee, Chih-Te , Novikova, Irina V. , Goldschmidt, Lukasz , McFarlane, Heather T. , Helguera, Gustavo F. , Evans, James E. , Sawaya, Michael R. , Cascio, Duilio , Eisenberg, David S. , Gonen, Tamir , Rodriguez, Jose A. and Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Publisher
United States: Nature Publishing Group
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English
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Publisher
United States: Nature Publishing Group
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Contents
The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the subångström- resolution structure of a protofibril formed by a wild-type segment from the β2–α2 loop of the bank vole prion protein. In this work, the structure of this protofibril...
Alternative Titles
Full title
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
Authors, Artists and Contributors
Author / Creator
Glynn, Calina
Boyer, David R.
Martynowycz, Michael W.
Hernandez, Evelyn
Miao, Jennifer
Zee, Chih-Te
Novikova, Irina V.
Goldschmidt, Lukasz
McFarlane, Heather T.
Helguera, Gustavo F.
Evans, James E.
Sawaya, Michael R.
Cascio, Duilio
Eisenberg, David S.
Gonen, Tamir
Rodriguez, Jose A.
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
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Record Identifier
TN_cdi_osti_scitechconnect_1843227
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1843227
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
