Reaction pathway engineering converts a radical hydroxylase into a halogenase
Reaction pathway engineering converts a radical hydroxylase into a halogenase
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Fe
II
/α-ketoglutarate (Fe
II
/αKG)-dependent enzymes offer a promising biocatalytic platform for halogenation chemistry owing to their ability to functionalize unactivated C–H bonds. However, relatively few radical halogenases have been identified to date, limiting their synthetic utility. Here, we report a strategy to expand the palet...
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Full title
Reaction pathway engineering converts a radical hydroxylase into a halogenase
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TN_cdi_osti_scitechconnect_1982157
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1982157
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-021-00944-x
