Single-cell, whole-embryo phenotyping of mammalian developmental disorders
Single-cell, whole-embryo phenotyping of mammalian developmental disorders
About this item
Full title
Author / Creator
Huang, Xingfan , Henck, Jana , Qiu, Chengxiang , Sreenivasan, Varun K. A. , Balachandran, Saranya , Amarie, Oana V. , Hrabě de Angelis, Martin , Behncke, Rose Yinghan , Chan, Wing-Lee , Despang, Alexandra , Dickel, Diane E. , Duran, Madeleine , Feuchtinger, Annette , Fuchs, Helmut , Gailus-Durner, Valerie , Haag, Natja , Hägerling, Rene , Hansmeier, Nils , Hennig, Friederike , Marshall, Cooper , Rajderkar, Sudha , Ringel, Alessa , Robson, Michael , Saunders, Lauren M. , da Silva-Buttkus, Patricia , Spielmann, Nadine , Srivatsan, Sanjay R. , Ulferts, Sascha , Wittler, Lars , Zhu, Yiwen , Kalscheuer, Vera M. , Ibrahim, Daniel M. , Kurth, Ingo , Kornak, Uwe , Visel, Axel , Pennacchio, Len A. , Beier, David R. , Trapnell, Cole , Cao, Junyue , Shendure, Jay , Spielmann, Malte and Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mouse models are a critical tool for studying human diseases, particularly developmental disorders
1
. However, conventional approaches for phenotyping may fail to detect subtle defects throughout the developing mouse
2
. Here we set out to establish single-cell RNA sequencing of the whole embryo as a scalable platform for the systemati...
Alternative Titles
Full title
Single-cell, whole-embryo phenotyping of mammalian developmental disorders
Authors, Artists and Contributors
Author / Creator
Henck, Jana
Qiu, Chengxiang
Sreenivasan, Varun K. A.
Balachandran, Saranya
Amarie, Oana V.
Hrabě de Angelis, Martin
Behncke, Rose Yinghan
Chan, Wing-Lee
Despang, Alexandra
Dickel, Diane E.
Duran, Madeleine
Feuchtinger, Annette
Fuchs, Helmut
Gailus-Durner, Valerie
Haag, Natja
Hägerling, Rene
Hansmeier, Nils
Hennig, Friederike
Marshall, Cooper
Rajderkar, Sudha
Ringel, Alessa
Robson, Michael
Saunders, Lauren M.
da Silva-Buttkus, Patricia
Spielmann, Nadine
Srivatsan, Sanjay R.
Ulferts, Sascha
Wittler, Lars
Zhu, Yiwen
Kalscheuer, Vera M.
Ibrahim, Daniel M.
Kurth, Ingo
Kornak, Uwe
Visel, Axel
Pennacchio, Len A.
Beier, David R.
Trapnell, Cole
Cao, Junyue
Shendure, Jay
Spielmann, Malte
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_2349056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_2349056
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-023-06548-w
