Insights into distinct signaling profiles of the µOR activated by diverse agonists
Insights into distinct signaling profiles of the µOR activated by diverse agonists
About this item
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Author / Creator
Qu, Qianhui , Huang, Weijiao , Aydin, Deniz , Paggi, Joseph M. , Seven, Alpay B. , Wang, Haoqing , Chakraborty, Soumen , Che, Tao , DiBerto, Jeffrey F. , Robertson, Michael J. , Inoue, Asuka , Suomivuori, Carl-Mikael , Roth, Bryan L. , Majumdar, Susruta , Dror, Ron O. , Kobilka, Brian K. , Skiniotis, Georgios and Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the mechanistic basis of action of lofentanil (LFT) and mitragynine pseudoindoxyl (MP), two μOR agonists with different safety profiles. LFT, o...
Alternative Titles
Full title
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Authors, Artists and Contributors
Author / Creator
Huang, Weijiao
Aydin, Deniz
Paggi, Joseph M.
Seven, Alpay B.
Wang, Haoqing
Chakraborty, Soumen
Che, Tao
DiBerto, Jeffrey F.
Robertson, Michael J.
Inoue, Asuka
Suomivuori, Carl-Mikael
Roth, Bryan L.
Majumdar, Susruta
Dror, Ron O.
Kobilka, Brian K.
Skiniotis, Georgios
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF)
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Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_2424019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_2424019
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-022-01208-y
