Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyon...
Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β-1,3-glucan synthesis inhibition
About this item
Full title
Author / Creator
Michigan State Univ., East Lansing, MI (United States) , Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL) , Dickwella Widanage, Malitha C. , Gautam, Isha , Sarkar, Daipayan , Mentink-Vigier, Frederic , Vermaas, Josh V. , Ding, Shi-You , Lipton, Andrew S. , Fontaine, Thierry , Latgé, Jean-Paul , Wang, Ping and Wang, Tuo
Publisher
United States: Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
United States: Nature Publishing Group
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Scope and Contents
Contents
AbstractAntifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins i...
Alternative Titles
Full title
Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β-1,3-glucan synthesis inhibition
Authors, Artists and Contributors
Author / Creator
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
Dickwella Widanage, Malitha C.
Gautam, Isha
Sarkar, Daipayan
Mentink-Vigier, Frederic
Vermaas, Josh V.
Ding, Shi-You
Lipton, Andrew S.
Fontaine, Thierry
Latgé, Jean-Paul
Wang, Ping
Wang, Tuo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_2480834
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_2480834
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50799-8
