Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme: the apoenzyme at 2.0 Å resolu...
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Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
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TN_cdi_osti_scitechconnect_913864
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_913864
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature03924
